Homéostasie gliale, neuroinflammation et neuroprotection

Direction

NeuroKines

1

Mitochondria are physiologically maintained at close to 50 °C.

Chrétien D, Bénit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs HT, Rustin P, RakM.

PLoS Biol. 2018 Jan 25;16(1):e2003992. 

 

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.

Krishnan ML, Van Steenwinckel J, Schang AL, Yan J, Arnadottir J, Le Charpentier T, Csaba Z, Dournaud P, Cipriani S, Auvynet C, Titomanlio L, Pansiot J, Ball G, Boardman JP, Walley AJ, Saxena A, Mirza G, Fleiss B, Edwards AD*, Petretto E*, Gressens P*.

Nat Commun. 2017 Sep 5;8(1):428

 

Association between early low-dose hydrocortisone therapy in extremely preterm neonates and neurodevelopmental outcomes at 2 years of age.

Baud O, Trousson C, Biran V, Leroy E, Mohamed D, Alberti C, for the PREMILOC Trial group.

 JAMA. 2017 Apr 4;317(13):1329-1337.

 

Functional ultrasound imaging of brain activity in human newborns.

Demene C, Baranger J, Bernal M, Delanoe C, Auvin S, Biran V, Alison M, Mairesse J, Harribaud E, Pernot M, Tanter M, Baud O.

Sci Transl Med. 2017 Oct 11;9(411).

 

Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures.

De Bundel D*, Fafouri A*, Csaba Z*, Loyens E, Lebon S, El Ghouzzi V, Peineau S, Vodjdani G, Kiagiadaki F, Aourz N, Coppens J, Walrave L, Portelli J, Vanderheyden P, Chai SY, Thermos K, Bernard V, Collingridge G, Auvin S, Gressens P, Smolders I*, Dournaud P*.

J Neurosci. 2015 Aug26;35(34):11960-75.

Capture d’écran 2019-02-08 à 15.32.39.pn

Pierre Gressens

DR Inserm

Pascal Dournaud

DR Inserm

 

 
 
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Golgi trafficking defects in postnatal microcephaly: The evidence for "Golgipathies".

Passemard S., Perez F., Colin-Lemesre E., Rasika S., Gressens P., El Ghouzzi V.

Prog. Neurobiol., 2017 Jun;153:46-63.

 

Cystic leukoencephalopathy with cortical dysplasia related to LAMB1 mutations.

Tonduti D, Dorboz I, Renaldo F, Masliah-Planchon J, Elmaleh-Bergès M, Dalens H, Rodriguez D, Boespflug-Tanguy O

Neurology. 2015 May 26;84(21):2195-7.

 

Haploinsufficiency of dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse.

Tata, B., Huijbregts, L., Jacquier, S., Csaba, Z., Genin, E., Meyer, V., Leka, S., Dupont, J., Charles, P., Chevenne, D., Carel, J.C., Leger, J., and de Roux, N.

PLoS Biol. 2014, 12:e1001952.

 

Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.

Cwerman-Thibault H, Reboussin E, Roussel D, Lai- Kuen R, Saubamea B, Sahel JA, Debeir T & Corral-Debrinski M.

Mol Ther. 2014; 22 (6): 1096-109.

 

Neuropathological review of 138 cases genetically tested for X-linked hydrocephalus: evidence for closely related clinical entities of unknown molecular bases

Adle-Biassette H, Saugier-Veber P, Fallet-Bianco C, Delezoide AL, Razavi F, Drouot N, Bazin A, Beaufrère AM, Bessières B, Blesson S, Bucourt M, Carles D, Devisme L, Dijoud F, Fabre B, Fernandez C, Gaillard D, Gonzales M, Jossic F, Joubert M, Laurent N, Leroy B, Loeuillet L, Loget P, Marcorelles P, Martinovic J, Perez MJ, Satge D, Sinico M, Tosi M, Benichou J, Gressens P, Frebourg T, Laquerrière A.

Acta Neuropathol., 2013, 126 : 427-442.

Dysfonctionnements cellulaires des anomalies du neurodéveloppement

Direction

2

NeuroDev 

 

 

 

 
 
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Odile

Boespflug-Tanguy

PU-PH

 

Nicolas de Roux

PU-PH

 

 
 
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Safety study of Ciprofloxacin in newborn mice.

Bourgeois T, Delezoide AL, Zhao W, Guimiot F, Adle-Biassette H, Durand E, Ringot M, Gallego J, Storme T, Le Guellec C, Kassaï B, Turner MA, Jacqz-Aigrain E, Matrot B.

Regul Toxicol Pharmacol. 2016 Feb;74:161-9.

 

Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study: results of a secondary multistate modelling analysis.

Eulenburg C, Wegscheider K, Woehrle H, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H, Cowie MR.

Lancet Respir Med. 2016 Nov;4(11):873-881.

 

Emotional disorders in adult mice heterozygous for the transcription factor Phox2b.

Bollen B, Ramanantsoa N, Naert A, Matrot B, Van den Bergh O, D'Hooge R, Gallego J.

Physiol Behav. 2015 Mar 15;141:120-6.

 

Protective effects of intermittent hypoxia on brain and memory in a mouse model of apnea of prematurity.

Bouslama M, Adla-Biassette H, Ramanantsoa N, Bourgeois T, Bollen B, Brissaud O, Matrot B, Gressens P, Gallego J.

Front Physiol. 2015 Nov 4;6:313. doi: 10.3389/fphys.2015.00313.

 

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C.

J Neurosci. 2011 Sep 7;31(36):12880-8.

Direction

3

Nouveaux outils pour le traitement des données physiologiques dans les troubles précoces du développement neurologique

NeoPhen 

Boris Matrot

IR Inserm

Christophe Delclaux

PU-PH

4

GenMedStroke 

 
 
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Génomique et médecine personnalisée dans les maladies cérébrovasculaires

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Disruption of a miR-29 binding site leading to COL4A1 upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy.

Verdura E, Hervé D, Bergametti F, Jacquet C, Morvan T, Prieto-Morin C, Mackowiak A, Manchon E, Hosseini H, Cordonnier C, Girard-Buttaz I, Rosenstingl S, Hagel C, Kuhlenbaümer G, Leca-Radu E, Goux D, Fleming L, Van Agtmael T, Chabriat H, Chapon F, Tournier-Lasserve E.

Ann Neurol. 2016 Nov;80(5):741-753.

 

Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.

Verdura E, Hervé D, Scharrer E, Amador Mdel M, Guyant-Maréchal L, Philippi A, Corlobé A, Bergametti F, Gazal S, Prieto-Morin C, Beaufort N, Le Bail B, Viakhireva I, Dichgans M, Chabriat H, Haffner C, Tournier-Lasserve E.

Brain. 2015 Aug;138(Pt 8):2347-58.

 

Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.

Hervé D, Philippi A, Belbouab R, Zerah M, Chabrier S, Collardeau-Frachon S, Bergametti F, Essongue A, Berrou E, Krivosic V, Sainte-Rose C, Houdart E, Adam F, Billiemaz K, Lebret M, Roman S, Passemard S, Boulday G, Delaforge A, Guey S, Dray X, Chabriat H, Brouckaert P, Bryckaert M, Tournier-Lasserve E

Am J Hum Genet. 2014 Mar 6;94(3):385-94.

 

Predictors and Clinical Impact of Incident Lacunes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Ling Y, De Guio F, Duering M, Jouvent E, Hervé D, Godin O, Dichgans M, Chabriat H.

Stroke. 2017 Feb;48(2):283-289.

 

Prediction of 3-year clinical course in CADASIL.

Jouvent E, Duchesnay E, Hadj-Selem F, De Guio F, Mangin JF, Hervé D, Duering M, Ropele S, Schmidt R, Dichgans M, Chabriat H.

Neurology. 2016 Oct 25;87(17):1787-1795

 
 
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Hugues Chabriat

PU-PH

 

 

Elizabeth

Tournier-Lasserve

PU-PH

 

 

Cortical Auditory-Evoked Responses in Preterm Neonates: Revisited by Spectral and Temporal Analyses.

Kaminska A, Delattre V, Laschet J, Dubois J, Labidurie M, Duval A, Manresa A, Magny JF, Hovhannisyan S, Mokhtari M, Ouss L, Boissel A, Hertz-Pannier L, Sintsov M, Minlebaev M, Khazipov R, Chiron C.

Cereb Cortex. 2017 Aug 11:1-16.

 

Relationships between Regional Radiation Doses and Cognitive Decline in Children Treated with Cranio-Spinal Irradiation for Posterior Fossa Tumors.

Doger de Speville E, Robert C, Perez-Guevara M, Grigis A, Bolle S, Pinaud C, Dufour C, Beaudré A, Kieffer V, Longaud A, Grill J, Valteau-Couanet D, Deutsch E, Lefkopoulos D, Chiron C, Hertz-Pannier L, Noulhiane M.

Front Oncol. 2017 Aug 18;7:166. 

 

Exploring the language networks in the human infant brain.

Dubois J, Poupon C, Thirion B, Simonnet H, Kulikova S, Leroy F, Hertz-Pannier L, Dehaene-Lambertz G.

Cereb. Cortex, 2016. 26(5):2283-2298.

 

Simplified gyral pattern in severe developmental microcephalies? New insights from allometric modeling for spatial and spectral analysis of gyrification.

Germanaud D, Lefèvre J, Fischer C, Bintner M, Curie A, des Portes V, Eliez S, Elmaleh-Bergès M, Lamblin D, Passemard S, Operto G, Schaer M, Verloes A, Toro R, Mangin JF, Hertz-Pannier L.

Neuroimage. 2014 Nov 15;102 Pt 2:317-31.

 

A revisited strategy for antiepileptic drug development in children: designing an initial exploratory step.

Chiron C, Kassai B, Dulac O, Pons G, Nabbout R.

CNS Drugs 2013.27(3):185-95.

Direction

Variabilité anatomo-fonctionnelle, vulnérabilité et plasticité au cours du neurodéveloppement : clinique, comportement et imagerie

InDEv

5

Jessica Dubois

CR Inserm

 

 

Lucie Hertz-Pannier

DR CEA