Homéostasie gliale, neuroinflammation et neuroprotection




Mitochondria are physiologically maintained at close to 50 °C.

Chrétien D, Bénit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs HT, Rustin P, RakM.

PLoS Biol. 2018 Jan 25;16(1):e2003992. 


Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.

Krishnan ML, Van Steenwinckel J, Schang AL, Yan J, Arnadottir J, Le Charpentier T, Csaba Z, Dournaud P, Cipriani S, Auvynet C, Titomanlio L, Pansiot J, Ball G, Boardman JP, Walley AJ, Saxena A, Mirza G, Fleiss B, Edwards AD*, Petretto E*, Gressens P*.

Nat Commun. 2017 Sep 5;8(1):428


Association between early low-dose hydrocortisone therapy in extremely preterm neonates and neurodevelopmental outcomes at 2 years of age.

Baud O, Trousson C, Biran V, Leroy E, Mohamed D, Alberti C, for the PREMILOC Trial group.

 JAMA. 2017 Apr 4;317(13):1329-1337.


Functional ultrasound imaging of brain activity in human newborns.

Demene C, Baranger J, Bernal M, Delanoe C, Auvin S, Biran V, Alison M, Mairesse J, Harribaud E, Pernot M, Tanter M, Baud O.

Sci Transl Med. 2017 Oct 11;9(411).


Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures.

De Bundel D*, Fafouri A*, Csaba Z*, Loyens E, Lebon S, El Ghouzzi V, Peineau S, Vodjdani G, Kiagiadaki F, Aourz N, Coppens J, Walrave L, Portelli J, Vanderheyden P, Chai SY, Thermos K, Bernard V, Collingridge G, Auvin S, Gressens P, Smolders I*, Dournaud P*.

J Neurosci. 2015 Aug26;35(34):11960-75.

Capture d’écran 2019-02-08 à 15.32.39.pn

Pierre Gressens

DR Inserm

Pascal Dournaud

DR Inserm


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Golgi trafficking defects in postnatal microcephaly: The evidence for "Golgipathies".

Passemard S., Perez F., Colin-Lemesre E., Rasika S., Gressens P., El Ghouzzi V.

Prog. Neurobiol., 2017 Jun;153:46-63.


Cystic leukoencephalopathy with cortical dysplasia related to LAMB1 mutations.

Tonduti D, Dorboz I, Renaldo F, Masliah-Planchon J, Elmaleh-Bergès M, Dalens H, Rodriguez D, Boespflug-Tanguy O

Neurology. 2015 May 26;84(21):2195-7.


Haploinsufficiency of dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse.

Tata, B., Huijbregts, L., Jacquier, S., Csaba, Z., Genin, E., Meyer, V., Leka, S., Dupont, J., Charles, P., Chevenne, D., Carel, J.C., Leger, J., and de Roux, N.

PLoS Biol. 2014, 12:e1001952.


Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.

Cwerman-Thibault H, Reboussin E, Roussel D, Lai- Kuen R, Saubamea B, Sahel JA, Debeir T & Corral-Debrinski M.

Mol Ther. 2014; 22 (6): 1096-109.


Neuropathological review of 138 cases genetically tested for X-linked hydrocephalus: evidence for closely related clinical entities of unknown molecular bases

Adle-Biassette H, Saugier-Veber P, Fallet-Bianco C, Delezoide AL, Razavi F, Drouot N, Bazin A, Beaufrère AM, Bessières B, Blesson S, Bucourt M, Carles D, Devisme L, Dijoud F, Fabre B, Fernandez C, Gaillard D, Gonzales M, Jossic F, Joubert M, Laurent N, Leroy B, Loeuillet L, Loget P, Marcorelles P, Martinovic J, Perez MJ, Satge D, Sinico M, Tosi M, Benichou J, Gressens P, Frebourg T, Laquerrière A.

Acta Neuropathol., 2013, 126 : 427-442.

Dysfonctionnements cellulaires des anomalies du neurodéveloppement







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Nicolas de Roux



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Safety study of Ciprofloxacin in newborn mice.

Bourgeois T, Delezoide AL, Zhao W, Guimiot F, Adle-Biassette H, Durand E, Ringot M, Gallego J, Storme T, Le Guellec C, Kassaï B, Turner MA, Jacqz-Aigrain E, Matrot B.

Regul Toxicol Pharmacol. 2016 Feb;74:161-9.


Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study: results of a secondary multistate modelling analysis.

Eulenburg C, Wegscheider K, Woehrle H, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H, Cowie MR.

Lancet Respir Med. 2016 Nov;4(11):873-881.


Emotional disorders in adult mice heterozygous for the transcription factor Phox2b.

Bollen B, Ramanantsoa N, Naert A, Matrot B, Van den Bergh O, D'Hooge R, Gallego J.

Physiol Behav. 2015 Mar 15;141:120-6.


Protective effects of intermittent hypoxia on brain and memory in a mouse model of apnea of prematurity.

Bouslama M, Adla-Biassette H, Ramanantsoa N, Bourgeois T, Bollen B, Brissaud O, Matrot B, Gressens P, Gallego J.

Front Physiol. 2015 Nov 4;6:313. doi: 10.3389/fphys.2015.00313.


Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C.

J Neurosci. 2011 Sep 7;31(36):12880-8.



Nouveaux outils pour le traitement des données physiologiques dans les troubles précoces du développement neurologique


Boris Matrot

IR Inserm

Christophe Delclaux




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Génomique et médecine personnalisée dans les maladies cérébrovasculaires


Disruption of a miR-29 binding site leading to COL4A1 upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy.

Verdura E, Hervé D, Bergametti F, Jacquet C, Morvan T, Prieto-Morin C, Mackowiak A, Manchon E, Hosseini H, Cordonnier C, Girard-Buttaz I, Rosenstingl S, Hagel C, Kuhlenbaümer G, Leca-Radu E, Goux D, Fleming L, Van Agtmael T, Chabriat H, Chapon F, Tournier-Lasserve E.

Ann Neurol. 2016 Nov;80(5):741-753.


Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.

Verdura E, Hervé D, Scharrer E, Amador Mdel M, Guyant-Maréchal L, Philippi A, Corlobé A, Bergametti F, Gazal S, Prieto-Morin C, Beaufort N, Le Bail B, Viakhireva I, Dichgans M, Chabriat H, Haffner C, Tournier-Lasserve E.

Brain. 2015 Aug;138(Pt 8):2347-58.


Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.

Hervé D, Philippi A, Belbouab R, Zerah M, Chabrier S, Collardeau-Frachon S, Bergametti F, Essongue A, Berrou E, Krivosic V, Sainte-Rose C, Houdart E, Adam F, Billiemaz K, Lebret M, Roman S, Passemard S, Boulday G, Delaforge A, Guey S, Dray X, Chabriat H, Brouckaert P, Bryckaert M, Tournier-Lasserve E

Am J Hum Genet. 2014 Mar 6;94(3):385-94.


Predictors and Clinical Impact of Incident Lacunes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Ling Y, De Guio F, Duering M, Jouvent E, Hervé D, Godin O, Dichgans M, Chabriat H.

Stroke. 2017 Feb;48(2):283-289.


Prediction of 3-year clinical course in CADASIL.

Jouvent E, Duchesnay E, Hadj-Selem F, De Guio F, Mangin JF, Hervé D, Duering M, Ropele S, Schmidt R, Dichgans M, Chabriat H.

Neurology. 2016 Oct 25;87(17):1787-1795

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Hugues Chabriat









Three-Dimensional Probabilistic Maps of Mesial Temporal Lobe Structures in Children and Adolescents' Brains.

Bouyeure A, Germanaud D, Bekha D, Delattre V, Lefèvre J, Pinabiaux C, Mangin JF, Rivière D, Fischer C, Chiron C, Hertz-Pannier L, Noulhiane M.

Front Neuroanat. 2018 Nov 15;12:98. 


Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics? 

Dinomais M, Hertz-Pannier L, Groeschel S, Delion M, Husson B, Kossorotoff M, Renaud C, Chabrier S, The Tich SN; AVCnn Study Group.

Stroke. 2016 Jun;47(6):1647-50. 


The dynamics of cortical folding waves and prematurity-related deviations revealed by spatial and spectral analysis of gyrification.

Dubois J, Lefèvre J, Angleys H, Leroy F, Fischer C, Lebenberg J, Dehaene-Lambertz G, Borradori-Tolsa C, Lazeyras F, Hertz-Pannier L, Mangin JF, Hüppi PS, Germanaud D. 

Neuroimage. 2019 Jan 15;185:934-946. 


Cortical Auditory-Evoked Responses in Preterm Neonates: Revisited by Spectral and Temporal Analyses.

Kaminska A, Delattre V, Laschet J, Dubois J, Labidurie M, Duval A, Manresa A, Magny JF, Hovhannisyan S, Mokhtari M, Ouss L, Boissel A, Hertz-Pannier L, Sintsov M, Minlebaev M, Khazipov R, Chiron C.

Cereb Cortex. 2018 Oct 1;28(10):3429-3444. 


Developmental trajectories of motor skills during the preschool period.

Peyre H, Albaret JM, Bernard JY, Hoertel N, Melchior M, Forhan A, Taine M, Heude B, De Agostini M, Galéra C, Ramus F; EDEN Mother-Child Cohort Study.

Eur Child Adolesc Psychiatry. 2019 Nov;28(11):1461-1474. 


Variabilité anatomo-fonctionnelle, vulnérabilité et plasticité au cours du neurodéveloppement : clinique, comportement et imagerie



Jessica Dubois

CR Inserm



Lucie Hertz-Pannier